Novel industrial crystallization technology for cefamandole nafate

• Main Author: TAO LINGGANG
• Format: Patent
• Language: English
• Published: 09.09.2015
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The invention discloses a novel industrial crystallization technology for cefamandole nafate. Recrystallization of the cefamandole nafate is realized through combination of a supercritical fluid extraction technology and a traditional crystallization technology. In a whole crystallization system, extraction, adsorption, crystallization and drying processes are finished under the coaction of a supercritical fluid, a solvent, an extraction pool and a crystallization pool under specific temperature and pressure conditions, and recrystallization of the cefamandole nafate is realized. According to the method, the separation efficiency is high, the product purity is high, few impurities exist, and the preparation product quality is greatly improved.