Composite thymosin enteric-coated tablet and preparation method thereof

• Main Authors: WANG WEI, YANG HUI, YU KAI, DONG ZHILING, FENG YUAN, LYU XUE, CHEN ZHU, XIAO YING, LU XUSHENG
• Format: Patent
• Language: English
• Published: 09.09.2015
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a thymosin enteric-coated tablet and a preparation method thereof, in particular to a composite thymosin enteric-coated tablet and a preparation method thereof, and aims to solve the problems of low release rate and high drug cost of existing thymosin preparations. The enteric-coated tablet comprises a drug-carrying microsphere, polyethylene glycol 3350, microcrystalline cellulose and magnesium stearate. The drug-carrying microsphere is made of thymosin, theaflavin and an enteric polymer auxiliary material. The preparation method includes 1, mixing the thymosin with the theaflavin and the enteric polymer auxiliary material to obtain a mixture, and adding the mixture into cosolvent to dissolve to obtain co-dissolved solution; 2, adopting a high-voltage static sprayer to spray the co-dissolved solution obtained in the step 1 to a powder reception plate to finally obtain the drug-carrying microsphere; 3, evenly mixing the drug-carrying microsphere with the microcrystalline cellulose, the polyethylene glycol 3350 and the magnesium stearate and tableting the mixture to obtain the thymosin enteric-coated tablet. The thymosin enteric-coated tablet and the preparation method thereof have the advantages that thymosin immunity can be enhanced through composition of the theaflavin and the thymosin, dosage of thymosin bulk drugs is reduced, and release rate of the enteric-coated tablet is high.