Novel benzazepine derivative and pharmaceutical use thereof

• Main Authors: ASANO YUKIYASU, KITAMOTO KATSUNORI, KUNO YUKA, GOTOH IZUMI, KURUMAZUKA DAISUKE, KATAOKA HIROYO, TAKEUCHI MITSUAKI, KASUGAI NOBUYOSHI, YAMADA YURIE, OHSAWA YASUSHI, HARADA SATOKO, TAKAHASHI NAOKI, OKABE MORIO, FUJIEDA HIROKI, IZUCHI TORU, SAKAI KEITA, MIYAZAWA TOSHIYUKI, NAGANO HIROKI
• Format: Patent
• Language: English
• Published: 02.09.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The objective of the present invention is to provide a compound which has V2 receptor agonistic activity. A pharmaceutical composition which contains, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. (In general formula (I), R1 represents a group represented by formula (2) or the like; R2 represents a hydrogen atom or a lower alkyl group; R3 represents a lower alkyl group which may be substituted by 1-3 fluorine atoms, or a halogen atom; R4 represents a five-membered aromatic monocyclic heterocyclic group, a five-membered non-aromatic monocyclic heterocyclic group or the like (provided that these heterocyclic groups have at least one nitrogen atom and may be substituted by a lower alkyl group); and R5 represents a lower alkyl group, a halogen atom or the like.) (In formula (2), A represents a lower alkylene group which may be substituted by a lower alkyl group, or the like; R6 represents a hydrogen atom or the like; and R7 represents a hydroxyl group, an aromatic heterocyclic group which may be substituted by a lower alkyl group, a carbamoyl group or the like.)