Preparation method for high-purity rosuvastatin calcium

• Main Authors: YU GAIGAI, YU YUHANG, AI YUDING, ZHAO SHENGXUAN, DAI CHUAN, CHEN YUYING
• Format: Patent
• Language: English
• Published: 22.07.2015
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The invention relates to preparation methods for compounds, in particular to a preparation method for high-purity rosuvastatin calcium. The preparation method comprises the following steps: in a N2 protection and light-shading environment, removing an acetonylidene protecting group in an acidic condition from an ester compound, hydrolyzing an ester bond in an alkali condition, regulating the pH (potential of hydrogen) value, adding active carbon for decoloration, performing extraction for removing impurities, dropwise adding a water soluble calcium salt solution, filtering and drying to obtain high-purity rosuvastatin calcium. The method adopts an alcohol solvent and the ester compound for synthesizing rosuvastatin calcium; an intermediate body is not separated in the process; rosuvastatin calcium is obtained with a one-pot procedure and is high in purity and high in yield; the process is simple, convenient and suitable for industrialized production.