Process for preparing 1-(2'-deoxy-2',2'-difluoro-D-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride

This invention provides a process for preparing gemcitabine hydrochloride which comprises deblocking beta -1-(2'-deoxy-2',2'-difluoro-3',5'-di-O-benzoyl-D-ribofuranosyl)-4-amin opyrimidin-2-one with a catalytic amount of an alkylamine in the presence of methanol or ethanol i...

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Bibliographic Details
Main Author R.A. BERGLUND
Format Patent
LanguageEnglish
Published 08.12.1999
Edition6
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:This invention provides a process for preparing gemcitabine hydrochloride which comprises deblocking beta -1-(2'-deoxy-2',2'-difluoro-3',5'-di-O-benzoyl-D-ribofuranosyl)-4-amin opyrimidin-2-one with a catalytic amount of an alkylamine in the presence of methanol or ethanol in an environment essentially free of water; treating the resulting solution with hydrochloric acid and an antisolvent; and recovering the resulting solid gemcitabine hydrochloride.
Bibliography:Application Number: CN19951096792