Refining method of D-glucosamine hydrochloride

• Main Authors: ZHANG LIBIAO, LI BINSHUI
• Format: Patent
• Language: English
• Published: 13.05.2015
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; SUGARS

The invention discloses a refining method of D-glucosamine hydrochloride, belongs to the technical field of D-glucosamine hydrochloride. The refining method comprises the specific steps as follows: (1), a crude D-glucosamine hydrochloride product is added to water in a mass ratio of 1: (2-6); (2), activated carbon is added to a feed liquid, the mixture is heated, subjected to backflow and filtered, filter residues are washed with water, filtrate and a cleaning solution are combined; (3), a mixed solution is pressed into a clean zone concentration tank and evaporated until solids are precipitated, a mixed solvent accounting for 2-5 times of the volume of the mixed solution is added to the concentration tank, the mixture is stirred uniformly, cooled and left to stand until crystal is precipitated, and the mixed solvent is prepared by mixing ethanol and isopropanol in a volume ratio of 1: (1-5); (4), filtering is performed to obtain the crystal, and the crystal is washed with a 75% mixed solvent aqueous solution and dried to obtain sterile D-glucosamine hydrochloride crystal. The method adopts the mixed solvent to crystallize the D-glucosamine hydrochloride feed liquid, the product yield is increased, and the production cost is reduced.