Preparation method for sodium zoledronic acid

• Main Authors: WANG DONGCHAO, LIU YUXIA, XIE MINGSHENG, LI GONGXIN, JIANG XIAOHAN, ZHANG QIAN, GUO HAIMING, HAO ERJUN, WANG HAIXIA
• Format: Patent
• Language: English
• Published: 13.05.2015
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a preparation method for sodium zoledronic acid, and belongs to the technical field of medicine synthesis. The technical scheme key point is that the preparation method for sodium zoledronic acid comprises the following steps: using a reaction medium as an ionic liquid, using imidazole-1-group acetic acid hydrochloride as a raw material, condensing with phosphoric acid and phosphorus trichloride, then hydrolyzing to prepare zoledronic acid monohydrate, and then carrying out reaction between zoledronic acid monohydrate and sodium hydroxide for salification so as to obtain the sodium zoledronic acid, wherein the ionic liquid is 1-n-butyl-3-methyl imidazolium tetrafluoroborate, N-ethyl pyridine tetrafluoroborate, 1-n-butyl-3-methyl imidazolium hexafluorophosphate, 1-ethoxyl-2,3-dimethyl imidazolium chloride, 1-nitrile propyl-3-methyl imidazolium chloride or 1-carboxyethyl-3-methyl imidazolium chloride. The preparation method has the advantages that the raw materials are highly available; the operation is simple and convenient; the yield and the product purity are high; the requirements of environmental protection and medicine production are met; the suitability for industrialized production is realized.