2-alkylamino-3-cyanobenzofuran type compound and preparation method thereof

The invention belongs to the technical field of chemical synthesis, and discloses a 2-alkylamino-3-cyanobenzofuran type compound and a preparation method thereof. The preparation method of the compound comprises the following steps: (1) dissolving 3-dehydroshikimic acid methyl ester and malononitril...

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Bibliographic Details
Main Authors WEI WEN, ZOU YONG, WANG DEJIAN, ZHANG ENSHENG, XU TIANLONG
Format Patent
LanguageEnglish
Published 22.04.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention belongs to the technical field of chemical synthesis, and discloses a 2-alkylamino-3-cyanobenzofuran type compound and a preparation method thereof. The preparation method of the compound comprises the following steps: (1) dissolving 3-dehydroshikimic acid methyl ester and malononitrile into a solvent A, reacting under a microwave condition, and filtering after the reaction to obtain an intermediate; and (2) performing microwave or oil-bath heating reaction on the intermediate obtained in the step (1) and a bromo-substance in a solvent B under the catalysis of alkali, and separating and purifying a reaction product to obtain the 2-alkylamino-3-cyanobenzofuran type compound. The method for preparing the 2-alkylamino-3-cyanobenzofuran type compound by taking a non-aromatic compound as an initiator is a brand-new method provided by the invention, and has the advantages of simple and easily-available raw material, mild reaction condition, simple operation, short reaction time, high yield and low cost.
Bibliography:Application Number: CN201410841114