5-(4-nitrophenyl)-3-hydroxylisoxazole and preparation process and use thereof

The invention relates to 5-(4-nitrophenyl)-3-hydroxylisoxazole and a preparation process and use thereof. The preparation process comprises the following steps: 1) by taking 4-nitrobenzaldehyde, triphenyl phosphine and ethyl chloroformate as initial raw materials, generating corresponding 3-(4-nitro...

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Bibliographic Details
Main Authors CHEN DA, LI YANG, LIU GENYAN, GU SHUANGXI, JU XIULIAN, LIU HUI, LU LI
Format Patent
LanguageEnglish
Published 22.04.2015
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
CHEMISTRY
FISHING
FORESTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HUNTING
METALLURGY
ORGANIC CHEMISTRY
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
TRAPPING
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Summary:The invention relates to 5-(4-nitrophenyl)-3-hydroxylisoxazole and a preparation process and use thereof. The preparation process comprises the following steps: 1) by taking 4-nitrobenzaldehyde, triphenyl phosphine and ethyl chloroformate as initial raw materials, generating corresponding 3-(4-nitrophenyl) ethyl acrylate by Witting reaction; 2) carrying out additive reaction on 3-(4-nitrophenyl) ethyl acrylate and bromine to generate corresponding ethyl 3-(4-nitrophenyl)-2, 3-dibromo propionate; and 3) carrying out reaction on ethyl 3-(4-nitrophenyl)-2, 3-dibromo propionate and hydroxylamine hydrochloride under the effect of sodium hydroxide to close the ring to generate corresponding 5-aryl-3-hydroxylisoxazole. The 5-(4-nitrophenyl)-3-hydroxylisoxazole provided by the invention has the beneficial effects that the 5-(4-nitrophenyl)-3-hydroxylisoxazole can be developed as an insecticide and has a wide application prospect.
Bibliography:Application Number: CN201410798040