Preparation method of (S)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonyl ethyl]-4-acetyl amino isoindoline-1, 3-diketone isomer

The invention discloses a preparation method of a (S)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonyl ethyl]-4-acetyl amino isoindoline-1, 3-diketone isomer. The preparation method comprises the following steps: preparing 1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethylamine chiral amino acid s...

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Bibliographic Details
Main Authors WU LING, PENG TAO, LIU BAOJIE
Format Patent
LanguageEnglish
Published 22.04.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses a preparation method of a (S)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonyl ethyl]-4-acetyl amino isoindoline-1, 3-diketone isomer. The preparation method comprises the following steps: preparing 1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethylamine chiral amino acid salt by virtue of a mixed solvent reaction, and then reacting with N-(1,3-dioxo-1,3-dihydrogen-isobenzofuran-4-yl)-acetamide under the condition proper for generate a final product. According to the preparation method disclosed by the invention, the prepared (S)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonyl ethyl]-4-acetyl amino isoindoline-1, 3-diketone isomer has the purity of at least 99 percent basically without containing other isomers, so that the effectiveness of a medicament preparation is ensured.
Bibliography:Application Number: CN20141791487