Method for synthesizing N,N'-bis-substituted fluoro malonamide compound

• Main Authors: YANG CUIFENG, LI BINGBO, WANG YUEMEI, WEI TIANQI, WU ZONGKAI, WANG LUN, LIN SHUANGZHENG
• Format: Patent
• Language: English
• Published: 22.04.2015
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a method for synthesizing an N, N'-bis-substituted fluoro malonamide compound. The method comprises the following steps: carrying out reaction between primary amino-compounds and fluoro malonate which are used as raw materials under a solvent-free condition to prepare the N, N'-bis-substituted fluoro malonamide compound, or carrying out reaction between primary amine acidic salt compound and fluoro malonamide which are adopted as raw materials in the existence of solvent and acid-binding agent to prepare the N, N'-bis-substituted fluoro malonamide compound. The method is simple to operate, rapid in reaction and high in yield, the difficulty for simply and rapidly synthesizing the N,N'-bis-substituted fluoro malonamide compound can be solved, and the method is suitable for the simple preparation in a laboratory and also suitable for large-scale preparation. The prepared compound can be used for synthesizing fluorine-containing organic molecules.