Synthetic method of L-dibenzoyl tartaric acid

• Main Authors: YUAN GUOLONG, WEN JIAOGANG, ZHENG JISHUAN, CUI QINGHAI, ZHANG JIANMIN, CHU JINGBO, FAN WEIBIN, LIU HANG, LI ZHIJUN, LI RONG, LI YAMIN, WANG JIANXUN, CUI FEI, ZHANG DAOWEI
• Format: Patent
• Language: English
• Published: 08.04.2015
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a synthetic method of L-dibenzoyl tartaric acid. The synthetic method comprises the following steps: with L-tartaric acid and benzoyl chloride as raw materials, copper sulfate as a catalyst and toluene as a solvent, carrying out reaction to prepare L-dibenzoyl tartaric anhydride, carrying out hydrolysis with an equal amount of water and toluene to obtain the L-dibenzoyl tartaric acid, wherein the toluene serving as the solvent, as well as the water and the toluene in the hydrolysis step can be repeatedly utilized. With the adoption of the synthetic method, the process is simple, the operation is safe and easy, the process recovery ratio achieves above 95 percent, meanwhile, the cost of the raw materials is low, a part of the raw materials can be recovered and recycled, and a finished product is high in purity and excellent in chiral separation performance.