Extraction condition optimization method and extraction method of tripterygium multi-index active ingredients

• Main Authors: XIAO HONGBIN, WANG LI, ZHUO RONGJIE, ZHANG XIAOZHE, GAO MINGZHE
• Format: Patent
• Language: English
• Published: 18.03.2015
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; METALLURGY; ORGANIC CHEMISTRY; STEROIDS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The invention relates to an extraction condition optimization method and an extraction method of tripterygium multi-index active ingredients. The extraction condition optimization method is characterized in that against optimal extraction of the tripterygium multi-index active ingredients, an ultrasonic extraction process of the tripterygium active ingredients in the prior art is integrated, through single-factor experimental investigation, three factors, namely liquid-to-solid ratio, solvent concentration and ultrasonic power, which have relatively great effects on extraction overall desirability value (OD value) of the tripterygium multi-index active ingredients, are selected, design expert software is utilized, and a star point design-response surface optimization method is applied for optimization, so that optimal extraction process parameters are obtained. The methods provided by the invention are simple, the experimental precision is high, the optimal values are calculated by model fitting, resources and energy consumption are saved, and a guide can be provided for industrialized extraction and production.