New application of miRNA-200b to preparation of beta-catenin inhibitor

• Main Authors: YANG AIJUN, MA DONGQING, CUI HONG, YANG LIJUN, ZHU LINHAN
• Format: Patent
• Language: English
• Published: 04.03.2015
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention relates to a non-coding nucleic acid for regulating gene expression, particularly new application of miRNA-200b to preparation of a beta-catenin inhibitor. According to the invention, overexpression and low expression of miR-200b are respectively conducted in hypoxic ischemic brain damage tissues, the protein expression condition of the beta-catenin inhibitor in the expression is detected, and results show that after overexpression of the miR-200b, the protein expression of the beta-catenin inhibitor is reduced, and meanwhile after the low expression of the miR-200b, the protein expression of the beta-catenin inhibitor is improved, so that the miR-200b participates in the repair process of the hypoxic ischemic brain damage through regulation and control of the protein expression of the beta-catenin. The invention provides new application of the miR-200b which can effectively regulate the protein expression of the beta-catenin and has significance on repairing the hypoxic ischemic brain damage.