Method for preparing alkylaryl amine compound through microwave synthesis

The invention discloses a method for preparing an alkylaryl amine compound through microwave synthesis. The method comprises the following steps of: reacting 3-dehydrogenated methyl shikimate and an alkylamine compound (formula 3) under the conditions of an organic solvent 1, a catalyst and a microw...

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Bibliographic Details
Main Authors WEI WEN, CHEN AIMIN, ZOU YONG, ZHANG ENSHENG, WANG DEJIAN, XU TIANLONG
Format Patent
LanguageEnglish
Published 25.02.2015
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a method for preparing an alkylaryl amine compound through microwave synthesis. The method comprises the following steps of: reacting 3-dehydrogenated methyl shikimate and an alkylamine compound (formula 3) under the conditions of an organic solvent 1, a catalyst and a microwave, so that the hexatomic ring skeleton of 3-dehydrogenated methyl shikimate is subjected to aromatization; after reaction liquid is cooled, pouring the reaction liquid into a large quantity of saturated salt solutions, fast stirring to precipitate a solid or extracting by using an organic solvent, drying, and carrying out column chromatography to obtain a 3-alkanamine-4-methyl hydroxybenzoate compound (formula I). The method disclosed by the invention can be used for obtaining the 3-alkanamine-4-methyl hydroxybenzoate compound by realizing the amine accelerating aromatization reaction of 3-dehydrogenated methyl shikimate by adopting microwave synthesis, and has the advantages of short reaction time, simplicity and convenience for operation, convenience for post-processing and cleanness in reaction.
Bibliography:Application Number: CN20141643079