Diammonium glycyrrhizinate enteric-coated sustained-release pellet and preparation method thereof

• Main Authors: WANG DIJIE, ZHANG DAQUAN, YAN JINGWU, DI CHUNSHENG, DU CHENGDE
• Format: Patent
• Language: English
• Published: 21.01.2015
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a diammonium glycyrrhizinate enteric-coated sustained-release pellet and a preparation method thereof, and belongs to the technical field of pellet preparation. The pellet comprises a pellet core, and a controlled-release layer and an enteric layer which sequentially coat outside the pellet core from inside to outside, wherein the controlled-release layer is prepared from the following components: 88-93 parts of ethyl cellulose, 4-6 parts of albumin and 4-6 parts of amino acid; and the enteric layer is prepared from the following components: 90-100 parts of methacrylate copolymer, 3-6 parts of lecithin, 0.2-0.9 part of sodium hydroxide and 17-22 parts of magnesium stearate. The pellet is prepared by the steps of preparing the pellet core, coating with the controlled-release layer and coating with the enteric layer. The pellet has the functions of solubilizing glycyrrhizic acid and improving the adhesion and permeating effect of glycyrrhizic acid on small intestine wall, and has relatively good intestine absorption effect and sustained-release effect.