Synthetic method of didanosine

The invention belongs to the technical field of organic synthesis and in particular relates to a synthetic method of didanosine. The synthetic method of didanosine comprises the following steps: carrying out reaction in presence of a metal salt catalyst with 2-acetoxyl isobutyryl chloride and inosin...

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Main Authors NIAN BEILEI, REN ZHEN, YIN HENGLIANG, WANG LI, MA ZHANBO, ZHU QIUSHENG, WANG XUEQIN, AN YONG, LI CUIPING, YAN DONGCHENG, WANG JIU, LIU PEI, ZHOU QIMEI, GAO MING, WANG JUNCHEN
Format Patent
LanguageChinese
English
Published 17.12.2014
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The invention belongs to the technical field of organic synthesis and in particular relates to a synthetic method of didanosine. The synthetic method of didanosine comprises the following steps: carrying out reaction in presence of a metal salt catalyst with 2-acetoxyl isobutyryl chloride and inosine as starting materials in acetonitrile, recycling acetonitrile to obtain chloride, suppressing the chloride in a solvent in presence of a glacial acetic acid catalyst by virtue of zinc powder, so as to obtain a suppressed substance, carrying out hydrolysis reaction on the suppressed substance in a protonic solvent under the alkali condition, so as to obtain sodium 2,3-dideoxy-2,3-didehydroinsoinate, and finally reacting in the presence of a catalyst, so that the didanosine finished product is obtained. The synthetic method of the didanosine has the advantages of good raw material stability, available raw materials, simple synthetic route, mild reaction conditions, low cost and high yield and is applicable to indus
Bibliography:Application Number: CN20141459870