Application of mercaptonicotinic acid compounds

The invention discloses application of substituted mercaptonicotinic acid compounds. The general structural formula of the compounds is shown in a formula I which is described in the specification, and the mercaptonicotinic acid compounds comprise pharmaceutically acceptable salts, esters and solvat...

Full description

Saved in:
Bibliographic Details
Main Authors WU YUELIN, ZHANG WANNIAN, LUO SEN, SHENG CHUNQUAN, YAO JIANZHONG, WANG QIN, MIAO ZHENYUAN, LIU XIONG, WANG HUI, LI TAO
Format Patent
LanguageChinese
English
Published 26.11.2014
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The invention discloses application of substituted mercaptonicotinic acid compounds. The general structural formula of the compounds is shown in a formula I which is described in the specification, and the mercaptonicotinic acid compounds comprise pharmaceutically acceptable salts, esters and solvates. Pharmacodynamic test results show that the mercaptonicotinic acid compounds as shown in the formula I can inhibit activity of botulinum neurotoxin endopeptidase and tetanus toxin endopeptidase in vitro and exert an obvious protective effect on mice poisoned by botulinum neurotoxin. Thus, the compounds provided by the invention can be used for preparation of drugs used for prevention and/or treatment of botulinum neurotoxin exposure and/or poisoning and for preparation of drugs used for prevention and/or treatment of tetanus.
Bibliography:Application Number: CN20131187415