Application of dsRNA or modification thereof in preparation of tumor inhibitor

• Main Authors: XIE WEIDONG, WU JIANGBIN, WANG JIU, ZHANG YAOU, HE JIE, XU NAIHAN
• Format: Patent
• Language: Chinese; English
• Published: 19.11.2014
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an application of a dsRNA (Double-stranded RNA) or a modification thereof in preparation of a tumor inhibitor. According to the application, the sequence of one strand of the dsRNA is SEQ ID No. 1 in the sequence table, and the sequence of the other strand of the dsRNA is SEQ ID No. 2 in the sequence table; the modification of the dsRNA is the dsRNA modification obtained by being modified through the steps of A1), A2) or A3) as follows: A1) modifying 2'-OH of the ribose of the dsRNA; A2) modifying the phosphate diester bond, used for being connected with the ribotide, of the dsRNA; A3) modifying the cholesterol connected with the 5' end of the ribose of the dsRNA. Experimental results show that the 2'-OMe-dsRNA21 or the modification thereof can effectively inhibit tumor and tumor cells.