Method for investigation of release degree of ibuprofen-pseudoephedrin hydrochloride sustained-release preparation

• Main Authors: WANG XIAOYAN, PENG LEI, ZHANG YI, WU DIKE, YE RUHAN, HUANG XIAOTANG, JIANG ZHIJUN
• Format: Patent
• Language: Chinese; English
• Published: 05.11.2014
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention discloses a method for investigation of a release degree of an ibuprofen-pseudoephedrin hydrochloride sustained-release preparation. A phosphate buffer solution added with lecithin is used as a release medium, an ibuprofen-pseudoephedrin hydrochloride sustained-release preparation is put into a rotation basket, the release medium is added into a dissolution cup, and a temperature of the release medium and a rotation rate of the rotation basket are controlled so that the ibuprofen-pseudoephedrin hydrochloride sustained-release preparation can release the compound ingredients in the release medium under the control. A comparison between release degrees of the ibuprofen-pseudoephedrin hydrochloride sustained-release preparation in a release medium without lecithin and in the release medium with lecithin proves that after use of an appropriate amount of lecithin in the phosphate buffer solution, release degrees of pseudoephedrine hydrochloride and ibuprofen in the ibuprofen-pseudoephedrin hydrochlor