Recombinant pseudorabies virus, construction method and application thereof

The invention discloses a recombinant pseudorabies virus (PRV), a construction method and application thereof. The recombinant pseudorabies virus takes recombinant PRV/TK<->/gE<->/EGFP<+> as the female parent, an expression cassette containing the main immunogenic gene ORF2 of porc...

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Bibliographic Details
Main Authors XIE XIAOYU, CHEN RUIAI, HE LING, REN CHANGBAO, HUANG HONGLIANG
Format Patent
LanguageChinese
English
Published 05.11.2014
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The invention discloses a recombinant pseudorabies virus (PRV), a construction method and application thereof. The recombinant pseudorabies virus takes recombinant PRV/TK<->/gE<->/EGFP<+> as the female parent, an expression cassette containing the main immunogenic gene ORF2 of porcine circovirus type 2 is inserted to replace an EGFP gene expression cassette in a gE gene so as to obtain the recombinant pseudorabies virus named as rPRV-ORF2. The recombinant pseudorabies virus provided by the invention is used for recombinant pseudorabies virus vaccines and has safety and effectiveness.
Bibliography:Application Number: CN20141183100