使用非糖基化载脂蛋白A-IV治疗糖尿病的方法

• Format: Patent
• Language: Chinese
• Published: 14.12.2016
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

本发明公开了治疗需要的受试者的2型糖尿病的方法和用于治疗2型糖尿病的药物组合物，其中本发明的方法和组合物是基于使用由蛋白质表达系统如细胞表达系统产生的非糖基化载脂蛋白A-IV。还公开了基于施用由蛋白质表达系统产生的非糖基化载脂蛋白A-IV基本上恢复需要的受试者的葡萄糖耐量到正常水平的方法和降低需要的受试者的血糖水平的方法。 Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed, wherein the methods and compositions of the invention are based on the use of non-glycosylated apolipoprotein A-IV produced by a protein expression system, such as a bacterial expression system. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject in need thereof based on administering non-glycosylated apolipoprotein A-IV produced by a protein expression system.