Neutralising antibodies to the major exotoxins TcdA and TcdB of clostridium difficile

This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.

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Bibliographic Details
Main Authors LIGHTWOOD DANIEL JOHN, HERVE KARINE JEANNINE MADELEINE, COMPSON JOANNE ELIZABETH, HUMPHREYS DAVID PAUL, FISHER NICOLA LOUISE, PAYNE ANDREW CHARLES, MACKENZIE BRENDON, PAGE MATTHEW JON TIMOTHY, KNIGHT DAVID EDWARD ORMONDE, COX MATTHEW, TYSON KERRY LOUISE
Format Patent
LanguageChinese
English
Published 30.07.2014
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.
Bibliography:Application Number: CN201280049537