Bicyclic heterocyclic compound

The invention is to provide a compound useful as the active ingredient in a drug composition for treating diseases to which 11beta-hydroxysteroid dehydrogenase type 1 contributes such as dementia, schizophrenia, depression, pain (particularly neuropathic pain and fibromyalgia), diabetes (particularl...

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Main Authors SEKIOKA RYUICHI, HAMAGUCHI WATARU, MORITOMO AYAKO, MORITOMO HIROYUKI, KAWANO NORIYUKI, SAKURAI MINORU, SHIRAISHI NOBUYUKI, SUZUKI KINOSU, KAWAKAMI SHIMPEI
Format Patent
LanguageChinese
English
Published 09.07.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention is to provide a compound useful as the active ingredient in a drug composition for treating diseases to which 11beta-hydroxysteroid dehydrogenase type 1 contributes such as dementia, schizophrenia, depression, pain (particularly neuropathic pain and fibromyalgia), diabetes (particularly type 2 diabetes), and insulin resistance. It was discovered that a bicyclic heterocyclic compound substituted with an acylamino group such as a (hetero)aroylamino group (the bicyclic heterocycle being formed by condensing a cyclohexane ring and a 5- or 6-membered monocyclic heterocycle having only a nitrogen atom as the heteroatom) or a pharmaceutically acceptable salt thereof has a superior selective inhibitory action with respect to 11beta-HSD1. Thus, the bicyclic heterocyclic compound can be used in the treatment of dementia, schizophrenia, depression, pain (particularly neuropathic pain and fibromyalgia), diabetes (particularly type 2 diabetes), insulin resistance, and the like
Bibliography:Application Number: CN201280051414