Glucagon-like peptide-2 analog, and preparation method and application thereof
The invention provides a glucagon-like peptide-2 (GLP-2) analog, and a preparation method and an application thereof. The sequence of the GLP-2 analog is HADX4SFSX8EMNTILDX16LAARDFIX24WLX27QTKITD n1X1C n2X2 represented by SEQ ID NO:1, wherein X4 is glycine or cysteine; X8 is aspartic acid or cystein...
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Main Authors | , , , , , , , |
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Format | Patent |
Language | Chinese English |
Published |
09.07.2014
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Subjects | |
Online Access | Get full text |
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Summary: | The invention provides a glucagon-like peptide-2 (GLP-2) analog, and a preparation method and an application thereof. The sequence of the GLP-2 analog is HADX4SFSX8EMNTILDX16LAARDFIX24WLX27QTKITD n1X1C n2X2 represented by SEQ ID NO:1, wherein X4 is glycine or cysteine; X8 is aspartic acid or cysteine; X16 is asparagine or cysteine; X24 is aspartic acid or cysteine; X27 is isoleucine or cysteine, only one of X4, X8, X16, X24 and X27 is cysteine, and cysteine is bonded with another cysteine through a disulfide bond; n1X1 represents n1 X1, and n1 is 1-30; and n2X2 represents n2 X2, and n2 is 0-30. The GLP-2 analog overcomes the short half life problem of GLP-2. |
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Bibliography: | Application Number: CN201310004367 |