Antibacterial chloroxoquinoline derivative

• Main Authors: RONG ZUYUAN, HU FULIAN, LUO ZHAOXUN, MO FEI, ZHANG RAN, YANG GUOZHEN, ZHANG SHUHUA, CAO RIHUI, ZHANG SHU, XIA SHUHUA, XIONG LIJUAN, ZHANG XUNYING, WANG ZIHOU, SUN CHAOQIN
• Format: Patent
• Language: Chinese; English
• Published: 18.06.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to an oxo-quinoline derivative with activity of resisting bacterial infection relevant diseases such as helicobacter pylori (Hp) infection disease. The invention specifically relates to a compound as shown in formula I in the specification, and a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R is selected from hydrogen, -C<1-6> alkyl, -C<2-6> alkenyl, -C<2-6> alkynyl, or -C<1-6> alkyl-phenyl, and the alkyl, alkenyl, alkynyl and phenyl can be randomly substituted by halogen, nitro, cyan, hydroxyl, -C<1-6> alkoxy and phenyl; R is selected from hydrogen, -CONHR and -COOR , R and R are independently selected from -C<1-6> alkyl and -C<1-6> alkyl amino, and the amino is randomly substituted by one to two -C<1-6> alkyls; R is selected from halogen, -C<1-6> alkoxy, morpholinyl or piperazinyl.