Tamper-resistant tablet providing immediate drug release

The invention relates to a tamper-resistant tablet comprising a matrix material in an amount of more than one third of the total weight of the tablet; and a plurality of coated particulates in an amount of less than two thirds of the total weight of the tablet; wherein said particulates comprise a p...

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Bibliographic Details
Main Authors SCHWIER SEBASTIAN, HAUPTS MARCEL, PAETZ JANA, BARNSCHEID LUTZ
Format Patent
LanguageChinese
English
Published 04.06.2014
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to a tamper-resistant tablet comprising a matrix material in an amount of more than one third of the total weight of the tablet; and a plurality of coated particulates in an amount of less than two thirds of the total weight of the tablet; wherein said particulates comprise a pharmacologically active compound and a physiologically acceptable polymer, preferably a polyalkylene oxide; and form a discontinuous phase within the matrix material; which preferably provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.
Bibliography:Application Number: CN201280038092