Refining method of valsartan containing more than 10% of isomer

The invention relates to a refining method of valsartan containing more than 10% of an isomer. The method comprises the following steps: dissolving by adding a solvent into valsartan containing more than 10% of the isomer, adding a certain amount of inorganic base to let a solid be precipitated afte...

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Bibliographic Details
Main Authors WANG PENG, CHEN JIAN, ZHANG WENLING, CHEN YONGBI
Format Patent
LanguageChinese
English
Published 28.05.2014
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a refining method of valsartan containing more than 10% of an isomer. The method comprises the following steps: dissolving by adding a solvent into valsartan containing more than 10% of the isomer, adding a certain amount of inorganic base to let a solid be precipitated after salt forming, filtering to obtain a filtrate, and vaporizing the filtrate to remove an organic solvent; acidifying the filtrate, extracting with an organic solvent, concentrating most of the organic solvent, and cooling for crystallization so as to obtain the product. By the method, the content of the isomer of the product can be less than 0.5%, and yield can reach up to more than 40%. The method provided by the invention is suitable for industrial production.
Bibliography:Application Number: CN2014163384