Refining method of valsartan containing more than 10% of isomer
The invention relates to a refining method of valsartan containing more than 10% of an isomer. The method comprises the following steps: dissolving by adding a solvent into valsartan containing more than 10% of the isomer, adding a certain amount of inorganic base to let a solid be precipitated afte...
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Main Authors | , , , |
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Format | Patent |
Language | Chinese English |
Published |
28.05.2014
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Subjects | |
Online Access | Get full text |
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Summary: | The invention relates to a refining method of valsartan containing more than 10% of an isomer. The method comprises the following steps: dissolving by adding a solvent into valsartan containing more than 10% of the isomer, adding a certain amount of inorganic base to let a solid be precipitated after salt forming, filtering to obtain a filtrate, and vaporizing the filtrate to remove an organic solvent; acidifying the filtrate, extracting with an organic solvent, concentrating most of the organic solvent, and cooling for crystallization so as to obtain the product. By the method, the content of the isomer of the product can be less than 0.5%, and yield can reach up to more than 40%. The method provided by the invention is suitable for industrial production. |
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Bibliography: | Application Number: CN2014163384 |