Vacuum pulse type method of preparing dihydromyricetin

• Main Author: YAO MAOJUN
• Format: Patent
• Language: Chinese; English
• Published: 07.05.2014
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The invention discloses a vacuum pulse type method of preparing dihydromyricetin. The method comprises the following steps: (1) drying and crushing a raw material medicinal material ampelopsis grossedentata to 20-80 meshes; (2) carrying out vacuum pulse type reflux extraction on the material by taking 5-95% of ethanol as a solvent, combining the extracting liquor, and concentrating, drying and crushing to obtain an ampelopsis grossedentata coarse extract; and (3) removing impurities with small polarity and strong lipid solubility of the ampelopsis grossedentata coarse extract by supercritical carbon dioxide, and crystallizing the extract twice by hot water to obtain an ampelopsis grossedentata refined extract. According to the method provided by the invention, under the condition of not using resin and column chromatography, the purity of dihydromyricetin reaches 92-98%, the product yield is improved by 10-15%, and the application range is wide.