Compound preparation of repaglinide and metformin hydrochloride

The invention relates to a preparation method for a compound preparation of repaglinide and metformin hydrochloride. The method includes: dissolving repaglinide in ethanol, dissolving an alkaline agent and a solubilizer in water, and then adding the obtained solutions into metformin hydrochloride an...

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Bibliographic Details
Main Authors CHEN QILONG, JIANG MEIJUAN, MEI ZHE, FANG SHENG, BAI XIAOYU, CHAN YUNXIA
Format Patent
LanguageChinese
English
Published 07.05.2014
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a preparation method for a compound preparation of repaglinide and metformin hydrochloride. The method includes: dissolving repaglinide in ethanol, dissolving an alkaline agent and a solubilizer in water, and then adding the obtained solutions into metformin hydrochloride and other auxiliary materials so as to prepare tablets. The method provided by the invention solves the problems of poor dissolubility of repaglinide, undesirable content uniformity and the like, and is suitable for industrialized mass production.
Bibliography:Application Number: CN20121407014