Preparation method for pitavastatin calcium intermediate

The invention discloses a preparation method for a pitavastatin calcium intermediate shown in the formula (I) of the Specification. According to the invention, the pitavastatin calcium intermediate is prepared from ester compounds shown in the formula (II) of the Specification through hydrolysis and...

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Bibliographic Details
Main Authors LIN SHIBO, ZHAO SHENGXUAN, LUO GANG, CHEN YUYING
Format Patent
LanguageChinese
English
Published 26.03.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a preparation method for a pitavastatin calcium intermediate shown in the formula (I) of the Specification. According to the invention, the pitavastatin calcium intermediate is prepared from ester compounds shown in the formula (II) of the Specification through hydrolysis and reduction; alcohol is used as hydrolysis medium, alcoholate can be formed by the alcohol and hydroxide, and the alkalinity of the alcoholate is stronger than that of the hydroxide, so that hydrolysis reaction is relatively facilitated; the hydrolysis time is 3-4 days when the hydrolysis medium in the prior art is an aqueous solution, while the hydrolysis time of the preparation method provided by the invention is less than 20 h.
Bibliography:Application Number: CN201310683234