Oral pharmaceutical dispersion compositions

The invention provides an oral pharmaceutical composition, optionally in dose unit form, comprising a lipophilic drug substance in dispersion in a physiologically tolerable aqueous carrier, preferably an aqueous gel, wherein the drug substance contains a functional electrostatic group having a pKa v...

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Bibliographic Details
Main Authors SETERNES TORE, HAUG INGVILD JOHANNE, DRAGET KURT INGAR, HATTREM MAGNUS, ENGELSEN STEINAR JOHAN
Format Patent
LanguageChinese
English
Published 12.03.2014
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention provides an oral pharmaceutical composition, optionally in dose unit form, comprising a lipophilic drug substance in dispersion in a physiologically tolerable aqueous carrier, preferably an aqueous gel, wherein the drug substance contains a functional electrostatic group having a pKa value of from 2 to 10, characterised in that said aqueous carrier has a pH at least 0.3 below or above the pKa value, said pH being below the pKa where said group is acidic and above the pKa where the group is basic.
Bibliography:Application Number: CN201180070775