Aminopyrimidines as SYK inhibitors

The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.

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Bibliographic Details
Main Authors DI FRANCESCO MARIA EMILIA, ZHOU HUA, GRIMM JONATHAN, CHILDERS KALEEN KONRAD, SCHELL ADAM J, ALTMAN MICHAEL D, HAIDLE ANDREW M, ELLIS JOHN MICHAEL, OTTE RYAN D, PETROCCHI ALESSIA, FISCHER CHRISTIAN, NORTHRUP ALAN B, KATTAR SOLOMON D
Format Patent
LanguageChinese
English
Published 05.03.2014
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
TRAPPING
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Summary:The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.
Bibliography:Application Number: CN201280032430