Riboflavin sodium phosphate injection and preparation process thereof

• Main Authors: ZHANG HONGYAN, RAO JIANPING, CAO YANLIN, CHEN CHONG, DENG MINMIN, ZUO FEIHONG, LI PING, LI JINJIN, ZHONG CHENGZAN, ZHANG XIN, OUYANG LIN, TU CHUANPING
• Format: Patent
• Language: Chinese; English
• Published: 29.01.2014
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a riboflavin sodium phosphate injection and a preparation process thereof. The prepared riboflavin sodium phosphate is more stable in content and relatively small in chromatic aberration in different batches. Saccharose, calcium disodium edentate, thiourea and methionine are selected as auxiliary materials, and after the saccharose, calcium disodium edentate, thiourea and methionine are proportioned, the stability of the riboflavin sodium phosphate injection can be improved, impurities in the injection are reduced, the content of riboflavin sodium phosphate is more stable, and the safety for clinical medication is improved. Raw materials are provided in different batches, the riboflavin sodium phosphate injection can also generate a certain color difference when made of the raw materials in the different batches, the color difference among all the batches of raw materials of the riboflavin sodium phosphate injection becomes more obvious after the auxiliary materials are added, but after