Vecuronium bromide freeze-dried powder injection for injection and preparation method thereof

• Main Authors: MENG CHEN, JI XINMING, ZHONG CHANGMAO
• Format: Patent
• Language: Chinese; English
• Published: 22.01.2014
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a vecuronium bromide freeze-dried powder injection for injection and a preparation method thereof. The vecuronium bromide freeze-dried powder injection for injection, provided by the invention, is prepared from the following raw materials: 4 g of vecuronium bromide, 5 to 7.5 g of mannitol, 5 to 7.5 g of lactose, 2.5 to 5 g of mycose, 3 to 3.5 g of citric acid, 6.5 to 7 g of disodium hydrogen phosphate and water for injection which is added until the volume is 1000 ml. The freeze-dried formula adopts combination of vecuronium bromide, mannitol, lactose, mycose, citric acid and disodium hydrogen phosphate and is combined with accurate freeze-drying process parameter control, so the appearance is full and not withered, the texture is loose and porous, the stability is high, the rehydration speed is high, and the requirement of the freeze-dried injection powder injection is met.