Compound, preparation method thereof and applications of compound in prevention of ulcerative colitis

• Main Authors: MA LI, GUO CHENNING, XIE JIAO, DONG YALIN, XING JIANFENG, XIAO ZHIQIANG, DONG KAI, YOU CUIYU
• Format: Patent
• Language: Chinese; English
• Published: 01.01.2014
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a compound, a preparation method thereof and applications of the compound in prevention of ulcerative colitis, and more specifically discloses bis{2-(butyroxy)-1-[(butyroxy)methyl]ethyl} 3, 3'-azo bis(6-hydroxybenzoic acid), and the preparation method and the applications thereof. The preparation method comprises following steps: 1, 3-dihydroxyacetone is taken as a synthesis raw material; a symmetrical compound 1, 3-dibutyryloxy-2-propanecarbonyl is synthesized; and dibutyrate 1, 3-dibutyryloxy-2-hydroxypropane is obtained by reduction of 1, 3-dibutyryloxy-2-propanecarbonyl; and then EDCI is taken as a dehydrating agent, DMAP is taken as a catalyst, and the target compound bis{2-(butyroxy)-1-[(butyroxy)methyl]ethyl} 3, 3'-azo bis(6-hydroxybenzoic acid) is obtained by ester condensation reaction of 1, 3-dibutyryloxy-2-propanecarbonyl and 3, 3'-azo bis(6-hydroxybenzoic acid). When bis{2-(butyroxy)-1-[(butyroxy)methyl]ethyl} 3, 3'-azo bis(6-hydroxybenzoic acid) is delivered into colon, 5-