Method for producing injectable formulations of blood-derived protein materials, and materials obtained using said method

The invention relates to a method for producing injectable pharmaceutical formulations of blood-derived protein materials, including the steps of fractioning the source material in a polymer/salt aqueous two-phasesystem in the presence of phenol, purifying the top phase of the system by means of pre...

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Main Authors VARGAS ARROYO MARIANGELA, LEON MONTERO GUILLERMO, VILLALTA ARRIETA MAUREN, HERRERA VEGA MARIA, SEGURA RUIZ ALVARO, ANGULO UGALDE YAMILETH
Format Patent
LanguageChinese
English
Published 25.12.2013
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a method for producing injectable pharmaceutical formulations of blood-derived protein materials, including the steps of fractioning the source material in a polymer/salt aqueous two-phasesystem in the presence of phenol, purifying the top phase of the system by means of precipitation with caprylic acid and purifying the bottom phase by means of thermocoagulation, increasing the purity of the materials in both phases through chromatography, removing viral particles by means of the nanofiltration of both preparations, and formulating, stabilizing, and packaging the resulting materials.
Bibliography:Application Number: CN201180070045