Application of Bostrycin to preparation of protein tyrodine phosphatase (PTP) bonding agents or inhibitors

The invention relates to the field of medicines, relates to a new application of Bostrycin and in particular relates to an application of Bostrycin to preparation of protein tyrodine phosphatase (PTP) bonding agents or inhibitors. By adopting the method, the PTP dephosphorylation inhibiting activity...

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Bibliographic Details
Main Authors HE LEI, LIN YONGCHENG, CHEN DONGNI, LU YONGJUN, SHE ZHIGANG
Format Patent
LanguageChinese
English
Published 18.12.2013
Subjects
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Summary:The invention relates to the field of medicines, relates to a new application of Bostrycin and in particular relates to an application of Bostrycin to preparation of protein tyrodine phosphatase (PTP) bonding agents or inhibitors. By adopting the method, the PTP dephosphorylation inhibiting activity of Bostrycin is found for the first time. The human PTP1B enzyme activity inhibiting activity IC50 of Bostrycin is 150mu M.
Bibliography:Application Number: CN20131259038