Pyrrole derivatives used as modulators of alpha7 nachr
The present invention is related to pyrrole derivatives of the formula I as the modulators of nicotinic acetylcholine receptors particularly the a7 subtype receptors. The invention includes the pyrrole derivatives, analogues, their prodrugs, their isotopes, their metabolites, pharmaceutically accept...
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Main Authors | , , , , , , |
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Format | Patent |
Language | Chinese English |
Published |
11.12.2013
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention is related to pyrrole derivatives of the formula I as the modulators of nicotinic acetylcholine receptors particularly the a7 subtype receptors. The invention includes the pyrrole derivatives, analogues, their prodrugs, their isotopes, their metabolites, pharmaceutically acceptable salts, polymorphs, solvates, optical isomers, clathrates, co-crystals, combinations with suitable medicament and pharmaceutical compositions thereof. The present invention also includes a process of preparation of the compounds and intended use in therapy of the compounds. Owing to the modulatory activity of the pyrrole derivatives on the nicotinic acetylcholine receptors, the invention finds applications in the prophylaxis and therapy of disorders encompassing the involvement of cholinergic transmission in the central and peripheral nervous systems. The invention relates to the capability of the pyrrole derivatives to modulate the cholinergic transmission and efficacy of the endogenous neurotransmitter ACh th |
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Bibliography: | Application Number: CN201280013694 |