Pyrrole derivatives used as modulators of alpha7 nachr

The present invention is related to pyrrole derivatives of the formula I as the modulators of nicotinic acetylcholine receptors particularly the a7 subtype receptors. The invention includes the pyrrole derivatives, analogues, their prodrugs, their isotopes, their metabolites, pharmaceutically accept...

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Main Authors KAMBOJ RAJENDER KUMAR, JANA GOURHARI, HATNAPURE GIRISH DHANRAJ, PALLE VENKATA P, SINHA NEELIMA, ADURKAR SHRIDHAR KESHAV, KARCHE NAVNATH POPAT
Format Patent
LanguageChinese
English
Published 11.12.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is related to pyrrole derivatives of the formula I as the modulators of nicotinic acetylcholine receptors particularly the a7 subtype receptors. The invention includes the pyrrole derivatives, analogues, their prodrugs, their isotopes, their metabolites, pharmaceutically acceptable salts, polymorphs, solvates, optical isomers, clathrates, co-crystals, combinations with suitable medicament and pharmaceutical compositions thereof. The present invention also includes a process of preparation of the compounds and intended use in therapy of the compounds. Owing to the modulatory activity of the pyrrole derivatives on the nicotinic acetylcholine receptors, the invention finds applications in the prophylaxis and therapy of disorders encompassing the involvement of cholinergic transmission in the central and peripheral nervous systems. The invention relates to the capability of the pyrrole derivatives to modulate the cholinergic transmission and efficacy of the endogenous neurotransmitter ACh th
Bibliography:Application Number: CN201280013694