Pridinol mesylate diclofenac sodium injection and preparation method thereof

The invention discloses a pridinol mesylate diclofenac sodium injection. The injection comprises the following components in every 100mL: 0.2g of pridinol mesylate, 2.5g of diclofenac sodium, 15-27mL of PEG400 (polyethylene glycol), 4-6mL of benzyl alcohol, 0.6g of mannitol, 0.3g of sodium pyrosulfi...

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Bibliographic Details
Main Authors WANG SHUAI, TAN MINGGUO, LUO YONGHUANG, WANG CUIYUAN, ZENG HAICHUN, LUO XIAOHONG, LONG FEI, LUO LEI, JIANG CAO
Format Patent
LanguageChinese
English
Published 11.12.2013
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses a pridinol mesylate diclofenac sodium injection. The injection comprises the following components in every 100mL: 0.2g of pridinol mesylate, 2.5g of diclofenac sodium, 15-27mL of PEG400 (polyethylene glycol), 4-6mL of benzyl alcohol, 0.6g of mannitol, 0.3g of sodium pyrosulfite, a sodium hydroxide solution used for regulating the pH to 8.0-8.6, and the balance of injection water. The injection water and PEG400 are of a mixed solvent, and assisted by benzyl alcohol to solve the technical problem that pridinol mesylate and diclofenac sodium are easily separated out in the preparation process; sodium pyrosulfite and mannitol are combined for resisting oxidation, so that the problem that the diclofenac sodium is not stable in a water solution can be solved; the injection is advanced in prescription, simple in preparation process, low in cost, stable, safe and effective, is suitable for intramuscular, subcutaneous or intravenous injection delivery, and is advantageous to fulfill the require
Bibliography:Application Number: CN20131389683