Method for synthesizing p-toluenesulfonic acid-catalyzed dimethyl malonate

• Main Authors: ZHENG DAOMIN, LIU JIA, LENG FANGRONG, LI CHAOQUAN, FAN QIANYU, ZHANG FEI, LI JING, HE YONGMEI, YAO RUJIE, DING YONGLIANG, QU YANG, WU CHUANLONG
• Format: Patent
• Language: Chinese; English
• Published: 04.12.2013
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The invention discloses a method for synthesizing p-toluenesulfonic acid-catalyzed dimethyl malonate. Chloroacetic acid is taken as a raw material, dimethyl malonate is generated through a neutralization reaction, a cyanation reaction, an acidification reaction, a hydrolysis reaction and an esterification reaction, the esterification reaction is performed under the catalytic effect of p-toluenesulfonic acid, a catalyst is recovered after the reactions, and the recovered catalyst can be recycled, so that the usage amount of the catalyst can be greatly reduced and sulfuric acid-containing wastewater cannot be produced by selecting p-toluenesulfonic acid instead of sulfuric acid in a traditional process as the catalyst in the esterification reaction; meanwhile, dichloroethane is added in the esterification reaction, has a good dissolving property for dimethyl malonate, is easily separated from dimethyl malonate through rectification and forms a ternary azeotropic system along with methanol and water, and the wat