Method for improving levodropropizine taste by solid dispersion

• Main Authors: WANG JUN, ZHOU YING, WANG HUIJUAN, GUO DONGGUI
• Format: Patent
• Language: Chinese; English
• Published: 06.11.2013
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a method for improving a levodropropizine taste by solid dispersion. The method comprises the step that levodropropizine is dispersed in one or more difficultly-dissolved auxiliary materials so that a solid dispersoid is produced, wherein the one or more difficultly-dissolved auxiliary materials are selected from difficultly-dissolved materials such as polyethylene glycol, povidone, organic acids, surfactants, cellulose, cellulose derivatives, ethyl cellulose, polyacrylic resin and sugar alcohol. The solid dispersoid is a difficultly-dissolved material and thus when a drug prepared from the solid dispersoid passes through a patient mouth cavity, dissolved levodropropizine is less so that the patient does not feel a peculiar smell and a bitter taste. Therefore, a levodropropizine taste is improved effectively and patient compliance is improved. The solid dispersoid of levodropropizine does not influence levodropropizine curative effects and can effectively improve levodropropizine clini