Classification of nucleic acid templates

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided...

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Bibliographic Details
Main Authors WEBSTER DALE, LYLE JOHN, WEGENER JEFFREY, KORLACH JONAS, VILFAN IGOR, TRAVERS KEVIN, JIA LEI, FLUSBERG BENJAMIN, TURNER STEPHEN, HEINER CHERYL, J. LI, SORENSON JON, PUGLISI JOSEPH, KISLYUK ANDREY, HANES JEREMIAH, MARKS PATRICK, TOMANEY AUSTIN B, CLARK TYSON A
Format Patent
LanguageChinese
English
Published 23.10.2013
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
COMPOSITIONS THEREOF
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
CULTURE MEDIA
ENZYMOLOGY
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROCESSES OF PREPARING SUCH COMPOSITIONS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
Bibliography:Application Number: CN201180064639