2-(butyryloxy)-5-amino benzoic acid, and preparation method and application thereof

The invention discloses 2-(butyryloxy)-5-amino benzoic acid, and a preparation method and an application thereof. According to the invention, 5-nitro salicylic acid and butyric acid are subjected to an esterification reaction; and nitro groups are reduced into amino groups, such that 2-(butyryloxy)-...

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Bibliographic Details
Main Authors MA LI, GUO CHENNING, XIE JIAO, DONG YALIN, XING JIANFENG, DONG KAI, SUN JINYUE, YOU CUIYU
Format Patent
LanguageChinese
English
Published 16.10.2013
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses 2-(butyryloxy)-5-amino benzoic acid, and a preparation method and an application thereof. According to the invention, 5-nitro salicylic acid and butyric acid are subjected to an esterification reaction; and nitro groups are reduced into amino groups, such that 2-(butyryloxy)-5-amino benzoic acid is obtained. When 2-(butyryloxy)-5-amino benzoic acid is orally taken and enters colon, 2-(butyryloxy)-5-amino benzoic acid can be degraded and 5-aminosalicylic acid and butyric acid can be released. The two acts upon a colonic lesion site together, and provide treatment effects.
Bibliography:Application Number: CN20131232460