Acarbose tablets and preparation method thereof

The invention discloses acarbose tablets and a preparation method thereof. The preparation method comprises the following steps of: uniformly mixing acarbose, microcrystalline cellulose, starch and 2/3 of carboxymethyl starch sodium to form a premix; pelletizing and granulating the premix through a...

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Bibliographic Details
Main Authors LIU QUANGUO, CHEN KELING
Format Patent
LanguageChinese
English
Published 25.09.2013
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses acarbose tablets and a preparation method thereof. The preparation method comprises the following steps of: uniformly mixing acarbose, microcrystalline cellulose, starch and 2/3 of carboxymethyl starch sodium to form a premix; pelletizing and granulating the premix through a dry process to obtain particles; and uniformly mixing the particles, 1/3 of carboxymethyl starch sodium, magnesium stearate and silicon dioxide, tabletting the mixture by a tablet press to obtain the acarbose tablets. According to the tablets prepared by dry-process palletizing and tabletting methods, the hardness and stability of the tablets are effectively improved and the problems of unaccepted disintegration time and unaccepted microorganisms are solved; as a result, the quality of the tablets is improved; and besides, the preparation method is simple in process flow, capable of saving energy source and cost, and suitable for industrial production.
Bibliography:Application Number: CN20131232803