Synthesis method of water-soluble derivative of lanthanide series metal loaded carbon nano material and application of water-soluble derivative

• Main Authors: WANG LEI, YU XIAOYUAN, GAO JUN, LIU YAN, MA ROUROU, SHI JINJIN, ZHANG ZHENZHONG, LIU RUIYUAN, ZHANG JING
• Format: Patent
• Language: English
• Published: 28.01.2015
• Subjects: CHEMISTRY; COMPOUNDS THEREOF; HUMAN NECESSITIES; HYGIENE; INORGANIC CHEMISTRY; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NANOTECHNOLOGY; NON-METALLIC ELEMENTS; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING

The invention relates to a synthesis method of a water-soluble derivative of a lanthanide series metal loaded carbon nano material and an application of the water-soluble derivative. The synthesis method can be used for effectively solving the problems of preparation of water-soluble derivatives of lanthanide series metal loaded carbon nano tubes and magnetic resonance contrast agents for tumor therapy. The method comprises the following steps of: adding the carbon nano material into mixed acid and hydrogen peroxide, ultrasonically reacting, performing suction filtration, washing the filtered product through water to be neutral, mixing the obtained carbon nano tube carboxylated product with an ammoniation reagent and N,N'-dicyclohexylcarbodiimide, performing ultrasonic dispersion on the mixture, heating, stirring to perform a backflow reaction, performing suction filtration, washing the filtered product through ethanol to be neutral, carrying out vacuum drying on the filtered product, putting the obtained carbon nano material ammoniated product in a mixed solvent, stirring, performing ultrasonic treatment, adding a solution A and a substance B, adding ethanol after a dissolution reaction, performing ultrasonic treatment, performing suction filtration, washing a filter cake through ethanol, adding ethanol, performing ultrasonic treatment, performing suction filtration, washing a filter cake through the solution A, adding the filter cake into ultrapure water, performing ultrasonic treatment, performing suction filtration, washing a filter cake through the ultrapure water, and carrying out vacuum drying to obtain the water-soluble derivative. The preparation method provided by the invention is simple and has a good use effect.