Method for preparing 4-aryl-6-methoxy carbonyl benzoxazinone compound

The invention discloses a method for preparing a 4-aryl-6-methoxy carbonyl benzoxazinone compound. The method comprises the steps of carrying out condensation, isomerization and dehydration reaction on 3-dehydrogenized methyl shikimate and aromatic primary amines in an organic solvent A under the ex...

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Bibliographic Details
Main Authors WEI WEN, ZOU YONG, ZHANG ENSHENG, XU TIANLONG, HUANG QI, HUANG TONGKUN, LV ZELIANG
Format Patent
LanguageChinese
English
Published 11.09.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a method for preparing a 4-aryl-6-methoxy carbonyl benzoxazinone compound. The method comprises the steps of carrying out condensation, isomerization and dehydration reaction on 3-dehydrogenized methyl shikimate and aromatic primary amines in an organic solvent A under the existence of a catalyst and a micro-wave condition; adding an acid-binding agent to a reaction system in ice bath, and gradually dropwise adding an organic solvent B in which chloroacetyl chloride is dissolved; and then heating and carrying out condensation reaction to obtain the 4-aryl-6-methoxy carbonyl benzoxazinone compound. The adopted material 3-dehydrogenized methyl shikimate is a non-aromatic compound, can be prepared from a renewable biomass resource shikimic acid by a simple method, and is obtained independently on a fossil resource; sustainable development and utilization can be achieved; and furthermore, a one-pot method and a microwave assisting method are adopted, so that the method is simple and conven
Bibliography:Application Number: CN20131221595