Preparation method of polylactic acid/carmustine drug carrying microsphere for malignant brain tumors

The invention provides a biodegradable olylactic acid/carmustine drug carrying system prepared by a spray drying method and belongs to the field of medicine entrapment and controllable release organisms. The preparation method comprises the following steps of: with ethyl acetate serving as a solvent...

Full description

Saved in:
Bibliographic Details
Main Authors SUN AIPING, LONG LIXIA, MENG YUBIN, YUAN XUBO
Format Patent
LanguageChinese
English
Published 11.09.2013
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The invention provides a biodegradable olylactic acid/carmustine drug carrying system prepared by a spray drying method and belongs to the field of medicine entrapment and controllable release organisms. The preparation method comprises the following steps of: with ethyl acetate serving as a solvent, preparing a polylactic acid solution; with typical antineoplastic drug naming carmustine serving as an entrapment substance, feeding polylactic acid and carmustine based on the mass ratio of (1:3)-(1:19); preparing the drug carrying microsphere at temperature of 40 DEG C; adjusting the loading quantity of samples of a liquid pump to 1.4 to 1.6L/h, hot air flow to 0.45 to 0.47m /min and high-pressure air output to 10L/min. The drug carrying microsphere prepared by the preparation method is high in spheronization, has the grain size of about 2.2 to 2.4 microns and meets the requirements for three-dimensional positioning and preparation injection. The preparation method of the drug carrying microsphere, provided by
Bibliography:Application Number: CN20131232387