Target SERS (Surface Enhanced Raman Scattering) probe with pH-sensitive drug release characteristic, and preparation method thereof
The invention discloses a target SERS (Surface Enhanced Raman Scattering) probe with pH-sensitive drug release characteristic. The probe comprises a Raman molecule-labeled gold nanoparticle core, a silicon dioxide intermediate layer, a mesoporous silica layer, a pH-sensitive polymer layer, a shell l...
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Main Authors | , , , |
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Format | Patent |
Language | Chinese English |
Published |
04.09.2013
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Subjects | |
Online Access | Get full text |
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Summary: | The invention discloses a target SERS (Surface Enhanced Raman Scattering) probe with pH-sensitive drug release characteristic. The probe comprises a Raman molecule-labeled gold nanoparticle core, a silicon dioxide intermediate layer, a mesoporous silica layer, a pH-sensitive polymer layer, a shell layer and a target ligand on the surface of the shell layer sequentially from inside to outside, the pH-sensitive polymer layer is a chitosan/polymethylacrylic acid layer, and the target ligand is transferrin. The invention further discloses a preparation method for the SERS probe. The probe and the preparation method thereof have the advantages that a pH-sensitive drug release system is combined with SERS, and the target ligand is connected with target tumor cells; the diffusion and release speed of drug in nano-particles can be regulated and controlled according to the pH value of the environment; the tracking on the nano-drug carrier particles can be more accurate through SERS signals in nano-drug carriers; and t |
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Bibliography: | Application Number: CN20131189083 |