Target SERS (Surface Enhanced Raman Scattering) probe with pH-sensitive drug release characteristic, and preparation method thereof

• Main Authors: FANG WEI, CUI YIPING, ZONG SHENFEI, WANG ZHUYUAN
• Format: Patent
• Language: Chinese; English
• Published: 04.09.2013
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a target SERS (Surface Enhanced Raman Scattering) probe with pH-sensitive drug release characteristic. The probe comprises a Raman molecule-labeled gold nanoparticle core, a silicon dioxide intermediate layer, a mesoporous silica layer, a pH-sensitive polymer layer, a shell layer and a target ligand on the surface of the shell layer sequentially from inside to outside, the pH-sensitive polymer layer is a chitosan/polymethylacrylic acid layer, and the target ligand is transferrin. The invention further discloses a preparation method for the SERS probe. The probe and the preparation method thereof have the advantages that a pH-sensitive drug release system is combined with SERS, and the target ligand is connected with target tumor cells; the diffusion and release speed of drug in nano-particles can be regulated and controlled according to the pH value of the environment; the tracking on the nano-drug carrier particles can be more accurate through SERS signals in nano-drug carriers; and t